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cftr modulators  (Vertex Pharmaceuticals)

 
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    Vertex Pharmaceuticals cftr modulators
    Cftr Modulators, supplied by Vertex Pharmaceuticals, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cftr modulators/product/Vertex Pharmaceuticals
    Average 86 stars, based on 1 article reviews
    cftr modulators - by Bioz Stars, 2026-05
    86/100 stars

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    A) Decision tree design depicting treatment sequence of the treat-all and predict-response strategies. Patients are allocated to either standard of <t>care</t> <t>(SoC)</t> or cystic fibrosis transmembrane conductance regulator <t>(CFTR)</t> modulators. B) Schematic representation of the Markov model structure in which pwCF either receive SoC or CFTR modulators. PwCF enter the model in the mild, moderate or severe health state, whereafter they move through model in yearly cycles. Solid arrows indicate the possible directions of movement. Dotted arrows represent the possibility of moving to a less severe health state which is only possible in the first cycle in the arm receiving CFTR modulators.
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    A) Decision tree design depicting treatment sequence of the treat-all and predict-response strategies. Patients are allocated to either standard of care (SoC) or cystic fibrosis transmembrane conductance regulator (CFTR) modulators. B) Schematic representation of the Markov model structure in which pwCF either receive SoC or CFTR modulators. PwCF enter the model in the mild, moderate or severe health state, whereafter they move through model in yearly cycles. Solid arrows indicate the possible directions of movement. Dotted arrows represent the possibility of moving to a less severe health state which is only possible in the first cycle in the arm receiving CFTR modulators.

    Journal: medRxiv

    Article Title: Early economic evaluation of a predictive tool to test CFTR modulator treatment response in people with cystic fibrosis

    doi: 10.64898/2026.01.12.26343787

    Figure Lengend Snippet: A) Decision tree design depicting treatment sequence of the treat-all and predict-response strategies. Patients are allocated to either standard of care (SoC) or cystic fibrosis transmembrane conductance regulator (CFTR) modulators. B) Schematic representation of the Markov model structure in which pwCF either receive SoC or CFTR modulators. PwCF enter the model in the mild, moderate or severe health state, whereafter they move through model in yearly cycles. Solid arrows indicate the possible directions of movement. Dotted arrows represent the possibility of moving to a less severe health state which is only possible in the first cycle in the arm receiving CFTR modulators.

    Article Snippet: Costs for SoC, CFTR modulator treatment (ETI, Trikafta®/Kaftrio®) by Vertex Pharmaceuticals Incorporated, Boston, MA, USA) and PEX-events were calculated using public list prices and reference prices from the Dutch Healthcare Institute and the Dutch Healthcare Authority [ - ].

    Techniques: Sequencing

    Journal: medRxiv

    Article Title: Early economic evaluation of a predictive tool to test CFTR modulator treatment response in people with cystic fibrosis

    doi: 10.64898/2026.01.12.26343787

    Figure Lengend Snippet:

    Article Snippet: Costs for SoC, CFTR modulator treatment (ETI, Trikafta®/Kaftrio®) by Vertex Pharmaceuticals Incorporated, Boston, MA, USA) and PEX-events were calculated using public list prices and reference prices from the Dutch Healthcare Institute and the Dutch Healthcare Authority [ - ].

    Techniques:

    The plot visualizes the impact of variation of individual parameters on the incremental cost-eAectiveness ratio by alternately varying input values between 80% (min, blue) and 120% (max, red) of their original value. CFTR = Cystic Fibrosis Transmembrane conductance Regulator, PEX = pulmonary exacerbation, ICER = Incremental Cost-EAectiveness Ratio.

    Journal: medRxiv

    Article Title: Early economic evaluation of a predictive tool to test CFTR modulator treatment response in people with cystic fibrosis

    doi: 10.64898/2026.01.12.26343787

    Figure Lengend Snippet: The plot visualizes the impact of variation of individual parameters on the incremental cost-eAectiveness ratio by alternately varying input values between 80% (min, blue) and 120% (max, red) of their original value. CFTR = Cystic Fibrosis Transmembrane conductance Regulator, PEX = pulmonary exacerbation, ICER = Incremental Cost-EAectiveness Ratio.

    Article Snippet: Costs for SoC, CFTR modulator treatment (ETI, Trikafta®/Kaftrio®) by Vertex Pharmaceuticals Incorporated, Boston, MA, USA) and PEX-events were calculated using public list prices and reference prices from the Dutch Healthcare Institute and the Dutch Healthcare Authority [ - ].

    Techniques: